Masculinizing Hormone Therapy (MHT) & Testosterone Prescriptions
At Pace Pharmacy, we understand that gender-affirming care is essential healthcare. Our specialized compounding services provide personalized masculinizing hormone therapy options for transgender men, nonbinary individuals, and others seeking physiological masculinization. With our expertise in custom medication formulation, we create testosterone preparations tailored to your specific needs and preferences.
What is Masculinizing Hormone Therapy?
Masculinizing hormone therapy (MHT) is a medical treatment that helps individuals achieve physical characteristics more aligned with their gender identity through the use of testosterone and other medications. This therapy is commonly sought by transgender men, nonbinary individuals designated female at birth (DFAB), and others seeking masculinization of their physical features.
MHT is a key component of gender-affirming care that can help alleviate gender dysphoria and improve quality of life for many individuals. At Pace Pharmacy, we understand the profound importance of accessing appropriate hormone therapy and work closely with healthcare providers to ensure patients receive optimal care.
How Does Masculinizing Hormone Therapy Work?
Testosterone is the primary hormone used in masculinizing hormone therapy. When introduced into the body in higher levels than typically present in people assigned female at birth, testosterone promotes the development of masculine secondary sexual characteristics, including:
- Deepening of the voice
- Increased muscle mass and strength
- Redistribution of body fat
- Growth of facial and body hair
- Cessation of menstruation
- Increase in skin oils and potential acne
- Enlarged clitoris
- Scalp hair loss (in those genetically predisposed)
The specific timeline and extent of these changes vary between individuals based on genetics, age, dosage, and other factors. Pace Pharmacy’s compounding capabilities allow us to create customized testosterone formulations that can be adjusted to achieve optimal results while minimizing unwanted side effects.
How to Start Testosterone
Starting testosterone therapy typically involves several steps:
- Consultation with a healthcare provider experienced in gender-affirming care, who can assess your health, discuss your goals, and determine appropriate treatment
- Medical evaluation including physical exams and baseline blood tests to check hormone levels and overall health
- Informed consent discussions about the potential effects, risks, and timeline of testosterone therapy
- Prescription for the appropriate testosterone formulation based on your needs and preferences
- Ongoing monitoring through regular follow-up appointments and laboratory tests
At Pace Pharmacy, we work collaboratively with your healthcare providers to ensure a smooth start to your testosterone therapy. Our pharmacists can answer questions about different administration methods, help troubleshoot any issues, and provide guidance on proper administration techniques.
How Masculinizing Hormone Therapy Supports Transgender & Nonbinary Identities

For many transgender men and transmasculine nonbinary individuals, masculinizing hormone therapy is a crucial aspect of gender affirmation. By bringing physical characteristics into better alignment with gender identity, MHT can significantly reduce gender dysphoria and improve psychological well-being.
MHT supports gender diverse individuals by:
- Facilitating physical changes that affirm gender identity
- Reducing distress associated with gender incongruence
- Improving social functioning and quality of life
- Supporting authentic self-expression
While not all transgender or nonbinary individuals desire hormone therapy, for those who do, access to appropriate care is vital. Pace Pharmacy is committed to providing respectful, knowledgeable service to all individuals seeking masculinizing hormone therapy, regardless of where they fall on the gender spectrum.
Is Testosterone Replacement Therapy the Same as Masculinizing Hormone Therapy?
While both testosterone replacement therapy (TRT) and masculinizing hormone therapy (MHT) utilize testosterone, they differ in their purpose and application:
Testosterone Replacement Therapy:
- Primarily prescribed to cisgender men with low testosterone levels
- Aims to restore testosterone to typical cisgender male physiological levels
- Treats conditions like hypogonadism, andropause, or other hormonal deficiencies
- Focuses on maintaining health and alleviating symptoms of low testosterone
Masculinizing Hormone Therapy:
- Primarily prescribed to transgender men, nonbinary individuals, and others seeking masculinization
- Aims to induce masculine physical characteristics
- Treats gender dysphoria by aligning physical traits with gender identity
- Focuses on gender affirmation and transition-related goals
At Pace Pharmacy, we compound testosterone for both purposes, ensuring that each patient receives a formulation that addresses their specific needs, whether for TRT or masculinizing hormone therapy.

Benefits & Potential Side Effects of Testosterone & Masculinizing Hormone Therapy
Benefits
Masculinizing hormone therapy can provide numerous physical and psychological benefits, including:
- Alignment of physical characteristics with gender identity
- Reduction in gender dysphoria
- Improved mental health and quality of life
- Development of desired masculine features
- Increased comfort in social situations
Potential Side Effects
While testosterone is generally well-tolerated, it’s important to be aware of potential side effects:
- Acne and oily skin
- Mood changes or irritability
- Increased risk of certain health conditions (cardiovascular issues, polycythemia)
- Changes in libido
- Hair loss in those genetically predisposed
Some individuals wonder: is testosterone bad for you? When properly prescribed and monitored, testosterone therapy is generally safe. However, it’s essential to work with healthcare providers who can help balance the benefits and risks based on your individual health profile.

What to Expect with Masculinizing Hormone Therapy
Changes from masculinizing hormone therapy occur gradually over months and years, similar to the timeline of puberty. While individual experiences vary, here’s a general timeline of what to expect:
First 3 months:
- – Skin oiliness/acne
- – Increased libido
- – Deepened voice
- – Increased muscle mass begins
- – Body fat redistribution begins
- – Cessation or reduction of menstruation
3-6 months:
- – Continued voice deepening
- – Continued muscle development
- – Facial hair begins to appear
- – Body hair thickens
- – Clitoral enlargement begins
6-12 months:
- – Voice continues to deepen
- – Significant facial and body hair growth
- – Further muscle development and fat redistribution
- – Clitoral enlargement continues
- – Scalp hair loss may begin in those genetically predisposed
1-2 years:
- – Voice reaches its final depth
- – Facial and body hair continue to develop
- – Body composition changes are more complete
2-5+ years:
- – Continued maturation of masculine features
- – Facial and body hair may continue to develop
The FTM testosterone experience varies widely between individuals. Some people see rapid changes, while others experience more gradual development. Pace Pharmacy can work with your healthcare provider to adjust your dosage and formulation to optimize your results.
Monitoring and Adjusting Your Hormone Therapy Safely
Regular monitoring is essential for safe and effective masculinizing hormone therapy. This typically includes:
- Blood tests to check testosterone levels
- Liver function tests
- Complete blood count (to monitor for elevated red blood cell counts)
- Lipid profiles
- Blood pressure monitoring
- Regular check-ins about physical and emotional changes
Your healthcare provider will use these results to adjust your testosterone dosage as needed. At Pace Pharmacy, we can work with your provider to reformulate your prescription based on these adjustments, ensuring you receive the optimal dose for your needs.
What happens when you stop taking testosterone?
- If you discontinue testosterone therapy, some changes will be permanent (such as clitoral enlargement, voice deepening and certain hair growth), while others will gradually reverse (such as fat distribution and muscle mass). This is why it’s important to understand that once you start testosterone therapy, you can stop if needed, but some effects will remain.
Testosterone Prescription Options: Injections, Creams, and Gels

There are several methods of testosterone administration, each with its own advantages:
Injections
- Most common and cost-effective method
- Typically administered weekly or bi-weekly
- Options include intramuscular or subcutaneous injections
- Provides consistent testosterone levels with proper scheduling
Testosterone Gel
- Applied daily to the skin
- Provides steady hormone levels
- Easy to use but must avoid skin contact with others
- Various formulations available, including custom compounded options
Testosterone Cream
- Applied to specific areas of the body
- May be less irritating for sensitive skin
- Custom compounded to specific strengths
- Important to know where to apply testosterone cream for optimal absorption
At Pace Pharmacy, we can compound various testosterone formulations to meet your specific needs and preferences. Our pharmacists can discuss the benefits of each method and help you find the one that works best for your lifestyle.
Personalized Care with Pace Compounding Solutions
As a specialty compounding pharmacy, Pace offers unique advantages for individuals seeking masculinizing hormone therapy:
- Customized formulations: We can adjust testosterone concentrations to achieve precise dosing
- Alternative delivery methods: Options for those who cannot use or prefer not to use standard formulations
- Preservative-free options: For individuals with sensitivities or allergies
- Combination formulations: Multiple active ingredients in a single preparation when appropriate
- Problem-solving expertise: Solutions for absorption issues or side effects experienced with commercial products
Our advanced compounding laboratory enables us to prepare testosterone in various forms, including creams, gels, and more, ensuring you receive the exact formulation that best suits your needs.
A Collaborative Process

At Pace Pharmacy, we believe in a collaborative approach to masculinizing hormone therapy. We work closely with:
- You: Listening to your goals, preferences, and concerns
- Your healthcare providers: Coordinating with physicians, nurse practitioners, and specialists to optimize your treatment
- Our compounding team: Leveraging our expertise to create the ideal formulation for your needs
This team-based approach ensures that your hormone therapy is tailored specifically to you, with adjustments made as needed based on your response and changing goals.

Frequently Asked Questions About Masculinizing Hormone Therapy
How long does it take to see results from Masculinizing Hormone Therapy?
Initial changes may begin within weeks, with significant changes developing over 1-2 years. Voice changes, increased muscle mass, and facial hair typically begin developing within 3-6 months, with continued changes occurring over several years.
What Masculinizing & Testosterone Treatments Are Available?
We offer various testosterone formulations including injections (cypionate and enanthate), gels, and creams. Your healthcare provider can help determine which option is best for your specific needs and preferences.
What are the side effects of Masculinizing Hormone Therapy?
Common side effects include acne, increased sweating, mood changes, increased appetite, and possible hair loss. More serious side effects that require monitoring include polycythemia (elevated red blood cell count), liver effects, and potential cardiovascular impacts.
Is Masculinizing Hormone Therapy reversible?
Some effects of testosterone are permanent (voice deepening, clitoral growth, and facial hair), while others are reversible (fat distribution, muscle mass, menstruation). It’s important to discuss the permanence of changes with your healthcare provider before starting therapy.
Is Testosterone Therapy reversible?
Similar to the above, testosterone therapy results in both permanent and reversible changes. Voice changes, facial/body hair growth, and clitoral growth are typically permanent, while changes in muscle mass, fat distribution, and skin oiliness may reverse if testosterone is discontinued.
Once you start Testosterone Therapy can you stop?
Yes, you can stop testosterone therapy at any time, though it’s recommended to do so under medical supervision. As mentioned, some changes will be permanent while others will gradually revert to pre-testosterone patterns.
How do I start Masculinizing Hormone Therapy with Pace Pharmacy?
To begin, you’ll need a prescription from a qualified healthcare provider. Once you have this prescription, contact Pace Pharmacy, and our team will guide you through the process, answer your questions, and prepare your customized hormone formulation.
Are there different options for starting testosterone?
Yes, there are multiple approaches to beginning testosterone therapy. Some providers use a gradual approach with slowly increasing doses, while others start with standard doses. The approach depends on your health status, goals, and preferences. Pace Pharmacy can work with your provider to create the appropriate starting regimen for you.
Is Masculinizing Hormone Therapy available for nonbinary/gender non-conforming individuals?
Absolutely. We recognize that nonbinary and gender non-conforming individuals may have specific goals for hormone therapy that differ from binary transgender men. We can work with your healthcare provider to create customized formulations that help you achieve your desired level of masculinization.
Is Masculinizing Hormone Therapy available for cisgender men?
Yes, cisgender men with low testosterone levels can benefit from hormone therapy (typically called testosterone replacement therapy or TRT). Pace Pharmacy compounds testosterone preparations for men with hypogonadism, age-related testosterone decline, and other medical conditions affecting testosterone levels.
Can I use hormone therapy to look more masculine without transitioning?
Yes, some individuals seek partial masculinization without full gender transition. This approach, sometimes called “microdosing,” can help achieve subtle changes. Our pharmacists can work with your healthcare provider to compound appropriate formulations for this purpose.
Is Masculinizing Hormone Therapy & Testosterone Therapy covered by OHIP?
OHIP does not directly cover the cost of hormone preparations, but some prescription drug plans may provide coverage. We recommend checking with your insurance provider about coverage details. For those without insurance coverage, we strive to provide cost-effective options.
At Pace Pharmacy, we’re committed to supporting your health journey with expertise, compassion, and personalized care. Our team understands the importance of appropriate hormone therapy and works diligently to provide high-quality, customized solutions for your masculinizing hormone therapy needs.
For more information or to transfer your prescription to Pace Pharmacy, contact us today. We look forward to being part of your healthcare team.
